Surv1ve-2 Trial

• Research type

  Research Study

• Full title

  SURV1VE 2-Trial - Sustained inflation and chest compression versus 3:1 chest compression to ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns – a multi-centre, international cluster randomized control trial

• IRAS ID

  365503

• Contact name

  Caroline Fray

• Contact email

  caroline.fray@albertahealthservices.ca

• Sponsor organisation

  The Governors of the University of Alberta

• Clinicaltrials.gov Identifier

  NCT06577818

• Duration of Study in the UK

  3 years, 7 months, 3 days

• Research summary

  Primary Research Question: Population (P), Intervention (I), Comparison (C), Outcome (O), Timeline (T): P In newborns between 28 to 43 weeks presenting with cardiac arrest at birth I does providing Cardiac compressions (CC)+Sustained inflation (SI) C compared to 3:1 Compression to ventilation (C:V) O decrease the incidence of neonatal mortality T within initial hospital stay?

  Hypotheses to be tested
  Primary hypothesis: The hypothesis for this study is that the incidence of neonatal mortality within initial hospital stay of life will be lower with CC+SI compared 3:1 C:V in newborns at birth.
  Secondary hypotheses: The benefits associated with CC+SI will i) reduce time to return of spontaneous circulation and ii) improve short- and long-term outcome.
  

• REC name

  Wales REC 5

• REC reference

  26/WA/0114

• Date of REC Opinion

  12 Jun 2026

• REC opinion

  Further Information Favourable Opinion