Surgically Correctable Congenital Malformations Affecting Lung Growth
Research type
Research Study
Full title
Surgically Correctable Congenital Malformations Affecting Lung Growth
IRAS ID
355159
Contact name
Adam Lawton
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
This research project will investigate how certain birth defects affecting the chest or abdomen impact children's breathing and exercise ability later in their childhood. Understanding these long-term effects will help families make informed decisions about their medical care, and will help medical professionals better understand these conditions and what support these children might need.
Participants will be children and young people who previously received medical care for specific birth defects at the Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, between 2000 and 2024. The specific conditions being investigated are; congenital lung malformations, congenital diaphragmatic hernia (CDH), fetal pleural effusions, gastroschisis, and omphalocele.
The study will take place at King's College Hospital, London. Participants will attend a single four-hour visit where they will undergo various lung function tests, complete questionnaires about any problems with breathing and how they impact on their quality of life, and participate in exercise tests. Participants and their parents/carers will also be interviewed to understand their unique perspectives on what matters most to them in terms of any breathing problems that might be related to their birth defect. Finally, we will use the postcode of participants to understand how factors like air quality and socioeconomic deprivation might influence lung health.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
25/SC/0340
Date of REC Opinion
7 Nov 2025
REC opinion
Further Information Favourable Opinion