Surgical prognostic markers in adult congenital heart disease patients
Research type
Research Study
Full title
Prognostic markers of adverse outcomes following surgery in adults with congenital heart disease
IRAS ID
290943
Contact name
Massimo Caputo
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Congenital heart disease (CHD) affects 8 in 1000 live births and encompasses a broad spectrum of conditions with varying severities. Through significant advances in operative and medical management, the life expectancy of this population has increased substantially, with 95% now surviving to adulthood.
Within this group of adults with CHD (ACHD), around 20% will require cardiac surgery or catheterisation as an adult. Complications following these procedures are well documented in the literature. Of note is the high incidence of post-operative acute kidney injury (AKI). Post-operative rates vary between 20-45% for milder impairments and up to 4% for severe impairment requiring renal replacement therapy. The presence of AKI is associated with higher mortality, longer ITU admissions, and long-term renal impairment.
The mechanism by which AKI develops is poorly understood. Identifying demographic, clinical and metabolomic risk factors for post-operative renal impairment is therefore invaluable in risk prediction, facilitating informed patient choice, personalising management strategies and pre-emptive risk reduction.
This study will use samples and data collected as part of the OMACS study to compare biomarkers and their ability to predict AKI and investigate novel demographic and clinical risk factors for developing AKI in an adult CHD population.
REC name
London - Surrey Research Ethics Committee
REC reference
21/PR/1442
Date of REC Opinion
18 Oct 2021
REC opinion
Favourable Opinion