SUNSHIELD
Research type
Research Study
Full title
Molecular photoprotection of the skin by natural and synthetic sunscreens and melanin
IRAS ID
139394
Contact name
Antony Young
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
We will study exogenous and endogenous photoprotection against solar radiation (UVR, visible light) induced molecular damage to the skin that may result in skin cancer. Exogenous protection will be assessed by applying synthetic sunscreens, natural marine sunscreens and natural DNA repair enzymes. Endogenous photoprotection will be determined by comparisons between people with white and black skins; the latter being very resistant to sunburn and skin cancer. The protective role of melanin will be evaluated as well as possible skin type dependent differences in the repair of DNA damage and other adverse responses to UVR exposure such as the generation of reactive oxygen species (ROS) and the antioxidant responses to ROS.
REC name
London - City & East Research Ethics Committee
REC reference
15/LO/0380
Date of REC Opinion
5 May 2015
REC opinion
Further Information Favourable Opinion