Study of tissue resident T cells and their regulation

• Research type

  Research Study

• Full title

  Tissue resident T cells: Investigation of their phenotype, function, regulation and potential roles in cancer and inflammation

• IRAS ID

  228026

• Contact name

  Oliver Nussbaumer

• Contact email

  oliver.nussbaumer@kcl.ac.uk

• Sponsor organisation

  GammaDelta Therapeutics Ltd

• Duration of Study in the UK

  5 years, 0 months, 0 days

• Research summary

  The research focuses on gamma delta (γδ) T cells, a unique, conserved population of lymphocytes that play a role in many immune responses and immunopathologies. A unique feature of these cells is their residency across several human epithelial sites such as the skin or the gut where these cells detect alterations of physiological normal self.

  In the proposed study we will isolate T cells, including tissue resident gamma delta T cells from human tissue and study their function and interactions with the aim of creating immunotherapies for cancer, including solid tumours and inflammatory diseases.

  Immunotherapy is the treatment of disease by inducing, enhancing, or suppressing an immune response. It can work to improve or restore immune system function in many different ways; for example in cancer it can potentially work by;

  Stopping or slowing the growth of cancer cells
  Stopping cancer from spreading to other parts of the body
  Helping the immune system work better at destroying cancer cells

  Immunomodulatory treatments often have fewer side effects than existing drugs, including less potential for creating resistance.

• REC name

  London - Camberwell St Giles Research Ethics Committee

• REC reference

  17/LO/0816

• Date of REC Opinion

  19 May 2017

• REC opinion

  Favourable Opinion