Study of ICAD Following Stroke Using 7T MRI
Research type
Research Study
Full title
7T MRI Vessel Wall Imaging of Symptomatic Intracranial Atherosclerosis in Acute Stroke: A Clinical Validation and Assessment of Feasibility Study
IRAS ID
352796
Contact name
Keith Muir
Contact email
Sponsor organisation
NHS Greater Glasgow & Clyde
Duration of Study in the UK
1 years, 0 months, days
Research summary
The study looks at intracranial atherosclerotic disease (ICAD), a condition where blood vessels in the brain become narrowed due to a build-up of cholesterol plaques. ICAD is a common cause of stroke and stroke reoccurrence. The study aims to understand how the instability of ICAD plaques affects stroke reccurrence using an MRI scanner with a strong magnetic field (7T).
The study will focus on patients who recently had a stroke or transient ischemic attack (TIA) where ICAD has been identified as a potential cause, based on routine scan findings.
The strong magnetic field of the 7T MRI scanner allows a higher level of detail to be obtained from scans. Understanding ICAD involves looking at the walls of the small blood vessels that supply the brain - structures that are difficult or impossible to see in detail with routine scanners. We hope to look for features that might indicate a higher risk of subsequent stroke, such as features that make atherosclerotic plaques unstable, or whether blood flow is restricted. We will therefore check electronic health records 6 months after the first scans to determine whether any further strokes have occurred.
The study aims to recruit 20 patients who meet the inclusion criteria above. They will undergo a 7T MRI scan, and their medical records will be checked 6 months post-initial stroke to see if they've had another stroke.REC name
West of Scotland REC 5
REC reference
25/WS/0081
Date of REC Opinion
23 Jun 2025
REC opinion
Favourable Opinion