Stromal derived factor-1 as a biomarker - v1
Research type
Research Study
Full title
Investigating the potential utility of stromal derived factor-1α as a biomarker in acute heart failure
IRAS ID
228557
Contact name
Ann-Marie Murtagh
Contact email
Sponsor organisation
Kings College NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 25 days
Research summary
Heart failure (HF) is a clinical syndrome characterised by low cardiac output or abnormal relaxation that typically results in pulmonary and peripheral congestion. SDF-1α is a naturally-occuring chemokine that is elevated in patients with HF, indicating a potential role as a biomarker. However, current interpretation of SDF-1α is complicated by the rapid degradation of full length active SDF-1α leading to the occurrence of truncated, inactive forms. Furthermore, standard ELISA assays do not distinguish between full length and cleaved SDF-1α. Although it is clear that SDF-1α plays a significant role in many diverse processes that accompany HF, the clinical utility of SDF-1α as a biomarker needs to be further elucidated by measuring full-length SDF-1α and correlating to clinical phenotypes. This study is designed to measure full-length SDF-1α in patients with acute heart failure compared to control subjects without heart failure.
REC name
London - Harrow Research Ethics Committee
REC reference
18/LO/1347
Date of REC Opinion
30 Nov 2018
REC opinion
Further Information Favourable Opinion