Stress biomarker profile in total knee replacements V1.0
Research type
Research Study
Full title
Determining the Stress Biomarker Profile in Patients Undergoing Total Knee Replacement: An Avenue to Improved Outcomes
IRAS ID
212309
Contact name
Andrew Metcalfe
Contact email
Sponsor organisation
UHCW NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
There is currently huge variability in outcomes and recovery following total knee replacement. Several studies have suggested that patient variation in physiological stress response may influence outcomes. Yet the response is poorly understood and bio markers not defined in the context of total knee replacement.
This prospective cohort study aims to describe the physiological stress biomarker profile for total knee replacement and determine any association with post-operative outcome measures.
This will help to inform current understanding of the variability in outcome following total knee replacement and also facilitate identification of potential targets for future therapies to improve outcome.
We propose to recruit 50 patients undergoing primary total knee replacement at two hospital sites (one large teaching hospital and one district general hospital). Participants will give saliva and blood samples for measurement of stress bio markers before the operation and at three time points following the operation. This will not influence normal care. Participants will also complete validated questionnaires before their operation and at 6 months and 12 months following their operation to assess baseline demographics, knee function and general health status.
REC name
London - West London & GTAC Research Ethics Committee
REC reference
16/LO/1789
Date of REC Opinion
1 Nov 2016
REC opinion
Further Information Favourable Opinion