STRATA: Predicting Response to Antipsychotic medication, Version 1.0

• Research type

  Research Study

• Full title

  STRATA: Predicting Response to Antipsychotic medication using clinical, social and genetic information (part of STRATA - Schizophrenia: Treatment Resistance and Therapeutic Advances)

• IRAS ID

  135762

• Contact name

  James H MacCabe

• Contact email

  james.maccabe@kcl.ac.uk

• Sponsor organisation

  King's College London

• Duration of Study in the UK

  2 years, 11 months, 31 days

• Research summary

  The aim of this project is to establish the extent to which genes influence clinical outcome in psychosis. Clinical outcome will be assessed in ~1,000 patients up to 8 years after their first presentation with psychosis. Participants of past psychosis studies will be re-contacted to avoid a selection bias towards chronic samples if recruited prospectively and long term response outcome is known. A summary approach to genetic information capture will rely on polygenic scoring methodologies and pathway analysis.

• REC name

  South Central - Oxford C Research Ethics Committee

• REC reference

  15/SC/0021

• Date of REC Opinion

  16 Feb 2015

• REC opinion

  Further Information Favourable Opinion