STOP-ADENOMA
Research type
Research Study
Full title
STudy Of Prevention by Aspirin anD EPA;kNowledge Of Mechanism of Action (STOP-ADENOMA)
IRAS ID
269560
Contact name
Mark Hull
Contact email
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
The seAFOod Trial showed that aspirin and a natural omega-3 fatty acid called EPA, reduce the number of polyps detected during a large bowel camera test (colonoscopy). We know that the higher the number of polyps that anyone has, the higher that person’s future risk of bowel cancer is. Therefore, aspirin and EPA both have potential for prevention of bowel cancer.
Aspirin and EPA reduced polyp number in different ways, depending on the type and location of the polyp. The trial also suggested that aspirin and EPA might work even better together. Therefore, we need to understand how aspirin and EPA work against polyps in order to use them most effectively for cancer prevention.
A major legacy of the seAFOod Trial is a collection of blood, urine and tissue samples, which were collected from over 90% of the 709 people in the trial. We have individual consent for research use of the samples and for access to colonoscopy results after the trial. Therefore, the seAFOod Trial team is in a unique position to;
1) test whether the reduction in bowel polyp recurrence persists at future colonoscopies, which will tell us whether long-term treatment is needed, or not.
2) measure the levels of several products of EPA and aspirin that are produced by the body. This will indicate whether combination treatment will give added benefit and identify a marker that predicts whether aspirin and/or EPA will work in any given individual.
3) test whether an EPA supplement, one’s genetic profile and/or omega-3 intake in the diet is important for whether aspirin prevents polyps and for whether EPA treatment will work. These results may lead to dietary guidance and identification of markers that match the best prevention agent, at the right dose, with the right person.REC name
London - Surrey Borders Research Ethics Committee
REC reference
19/LO/1655
Date of REC Opinion
16 Oct 2019
REC opinion
Favourable Opinion