STICH3-BCIS4
Research type
Research Study
Full title
A multicentre randomised trial of surgical versus percutaneous revascularisation of ischaemic left ventricular dysfunction (iLVSD) in the United Kingdom, with embedded internal pilot and health economic analysis
IRAS ID
329409
Contact name
Gavin Murphy
Contact email
Sponsor organisation
University of Leicester
Duration of Study in the UK
8 years, 4 months, 29 days
Research summary
Heart failure affects 1-2% of the population and is increasing in prevalence due to a growing, ageing, more sedentary population, and improved management of heart attacks. Heart failure causes severe, debilitating symptoms, high rates of mortality, frequent long hospitalisations, and costs the NHS £2 billion per year (2% of the total NHS budget). Coronary artery disease (CAD) is the most common cause of heart failure, responsible for 52% of cases in patients under 75 years of age, and is the primary cause of heart failure where the heart is not pumping sufficient blood.
We are comparing two treatments to restore blood flow to the part of the heart where flow is limited or blocked:
•Percutaneous coronary intervention (PCI)- a minimally-invasive procedure that restores blood flow from the inside.
•Coronary artery bypass (CABG) - surgery where a bypass (detour) is created around a blocked section of an artery.Both PCI and CABG are currently offered to patients in the NHS. This trial aims to understand which type of procedure is better for patients with ischaemic left ventricular dysfunction (iLVSD) plus CAD, which type will lead to a better quality of life for the patient and which is better resource-wise for the NHS.
REC name
London - Queen Square Research Ethics Committee
REC reference
24/LO/0246
Date of REC Opinion
19 Apr 2024
REC opinion
Further Information Favourable Opinion