SteatoSITE2 – accelerating research into MASLD

• Research type

  Research Database

• IRAS ID

  352218

• Contact name

  Timothy Kendall

• Contact email

  tim.kendall@ed.ac.uk

• Research summary

  SteatoSITE2 – accelerating research into metabolic dysfunction-associated steatotic liver disease

• REC name

  West of Scotland REC 4

• REC reference

  25/WS/0004

• Date of REC Opinion

  16 Jan 2025

• REC opinion

  Favourable Opinion

• Data collection arrangements

  The SteatoSITE2 database will store the following data:
  - Clinical care information which is related to the liver disease under study (metabolic dysfunction-associated steatotic liver disease)
  - Details from the pathology review of the liver samples taken as part of patients care
  - new genetic data generated by the study related to the liver disease
  At this time all of the data has already been collected by the SteatoSITE team with the support from NHS Safe Haven teams who control all patients NHS data. Any other relevant data required will be subject to ethical approval and will be supported in the same way by NHS Safe Haven teams

• Research programme

  Metabolic dysfunction-associated steatotic liver disease (MASLD) now affects around 38% of people worldwide. A key challenge in MASLD is the identification of patients who are at greatest risk of development of the progressive form of the disease, which has life limiting outcomes. By incorporating data from clinical records, along with imaging, pathology, and genetic data (RNA sequencing), we have built up a data set which can be searched for information on changes occurring at different stages of the disease to track adverse outcomes. The database can also be used to find or validate potential predictors of poor outcomes and look at any potential treatments which may could be tested to help these patients. By drawing on patients from Scotland, with its stable population and unified health care system, and using the data already in existence, we can rapidly generate a significant resource for scientists and doctors to investigate without the requirement of having to wait to recruit patients at diagnosis and follow for a long time which will help to meet the urgent medical needs of this growing patient population.

• Research database title

  SteatoSITE2 – accelerating research into metabolic dysfunction-associated steatotic liver disease

• Establishment organisation

  University of Edinburgh

• Establishment organisation address

  Institute for Regeneration and Repair

  Edinburgh BioQuarter

  4-5 Little France Drive, Edinburgh

  EH16 4UU