Standard Care versus Triventricular Pacing in Heart Failure (STRIVE HF)
Research type
Research Study
Full title
A multicentre randomised control trial comparing standard cardiac resynchronisation pacing with triventricular pacing
IRAS ID
170760
Contact name
C A Rinaldi
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Many patients with heart failure have problems with the electrical impulses that cause the heart to contract resulting in unsynchronised and inefficient contraction. Special pacemakers called cardiac resynchronisation devices have been developed that correct this problem. Not only do these devices improve patients's heart failure symptoms, they also prolong life. They work by placing one pacing wire in the right side of the heart and one on the outside of the left main pumping chamber via a vein that runs over the heart. However, they only work 50-70% of the time and it is not possible to predict fully who will benefit and who won't. One suggestion to reduce this "non-response" is to add an extra lead in a different vein running over the left side of the heart. Small studies have for the most part been positive but it is important to determine whether the extra lead does make a real difference to patient outcomes. We therefore propose to invite 100 patients to have either standard care or the pacemaker with the third lead (following randomisation) and we will investigate whether there is a difference in the outcomes.
REC name
London - Surrey Research Ethics Committee
REC reference
15/LO/0183
Date of REC Opinion
17 Mar 2015
REC opinion
Further Information Favourable Opinion