SSS Study Version 1.0
Research type
Research Study
Full title
Study of Sulphonylurea Synergy with DPP4 Inhibibtors
IRAS ID
266525
Contact name
Ewan R Pearson
Contact email
Sponsor organisation
University of Dundee
Duration of Study in the UK
1 years, 5 months, 7 days
Research summary
Insulin is the chemical signal that controls your blood sugar level. Type 2 diabetes is an illness where the body doesn't make enough insulin, or insulin doesn't work properly causing high blood sugar levels. When the stomach receives food, the digestive system sends out signals known as "incretins". Incretins tell the pancreas to prepare to release insulin. Therefore, boosting incretins can help treat Type 2 Diabetes.
Our previous research has found that a very low dose of a diabetes medicine called a sulphonylurea (sul-fon-yl-ur-ee-a) works with incretins to boost insulin levels. We would like to see if we can improve sugar levels further using a very low dose of sulphonylurea with another medicine which boosts the incretin effect - it is called a "DPP4 Inhibitor".
We will test how these medicines work on their own, and together. In this study, participants will take these medicines once a day at home in different combinations over 8 weeks. We will measure how blood sugar levels change during participants everyday life using a special sugar sensor, and during four milkshake meal tests at The Clinical Research Centre at Ninewells Hospital in Dundee.We are looking for participants with Type 2 Diabetes who are treated with diet alone, or with a tablet called metformin.
All potential participants will be given an information pack. An initial visit will ensure they understand the study, answer any questions, check initial bloods to make sure they are safe to participate and sign a consent form. At the next visit, we will apply the sugar sensor - it fits like a sticker to the back of their arm. It is very comfortable, and will automatically measure their sugar levels during the study.
The next four visits will be for milkshake meal tests which will test sugar, insulin and incretin levels after a meal.REC name
East of Scotland Research Ethics Service REC 1
REC reference
19/ES/0092
Date of REC Opinion
2 Sep 2019
REC opinion
Further Information Favourable Opinion