SPITFIRE v1.6
Research type
Research Study
Full title
Single-Cell Sequencing analysis of Radiation Pneumonitis signals In patients Treated For cancer with Radiotherapy
IRAS ID
339413
Contact name
Stephen Harrow
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Radiation pneumonitis is an inflammatory reaction within the lung caused by radiotherapy and the dose-limiting toxicity to delivering treatment for cancer within the chest. It is very poorly understood with limited treatment options and often comes with significant morbidity and mortality. Other than general supportive measures there has only been steroids and this has not changed in years. Five patients with clinically or radiologically confirmed radiation pneumonitis who have been referred for a bronchoscopy will have had a deep bronchial brushing obtained via the ELFMAN Protocol. ELFMAN is the Edinburgh Lung Fibrosis Molecular Endotyping study and proposes to better characterize suspected inflammatory and fibrotic interstitial lung disease, which may have shared molecular and cellular changed with interstitial pneumonias including idiopathic pulmonary fibrosis. One of these tissue samples can be analyzed using a relatively novel technique of single-cell sequencing to identify which cells are being up/down regulated and in doing so shine light on the mechanisms underpinning it, hopefully revealing new targets for the treatment of tomorrow. This proof-of concept trial aims demonstrate that the combination of bronchoscopy brushings and single-cell sequencing can successfully reveal molecular activity behind the radiation pneumonitis process.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
24/PR/1028
Date of REC Opinion
17 Oct 2024
REC opinion
Further Information Favourable Opinion