SPIRE MI v1
Research type
Research Study
Full title
Is microspirometry a reliable alternative to conventional spirometry for patients hospitalised with acute myocardial infarction? (The SPIRE-MI study)
IRAS ID
354102
Contact name
William A E Parker
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 9 months, 28 days
Research summary
Smoking is a risk factor for heart attack and a lung condition called chronic obstructive pulmonary disease or COPD. COPD can cause cough and difficulty breathing.
It is particularly important for us to pick up COPD in patients with heart attack so that it can be treated, as this improves not only lung health but also heart health.
COPD is diagnosed using a breathing test called spirometry. There are different types of spirometry machine. The COPD-6 microspirometer is a small, simple, affordable and portable device. The conventional spirometer is larger, more expensive, more complex and less portable.
In previous research, we used the COPD-6 microspirometer to measure the lung function of people in hospital for heart attack with significant history of smoking. We found around 1 in 5 of the people we tested had evidence of COPD, and in around three-quarters of cases a diagnosis of COPD had not previously been made.
The COPD-6 microspirometer would be ideal for detecting COPD in patients with heart attack while they are in hospital, but we are not sure if it performs as well as a standard spirometer device. This research will compare the two devices. 100 people in hospital because of a heart attack who have a significant smoking history will be asked to take part, recruited over 10 months. After taking written informed consent, they will undergo spirometry using both the COPD-6 microspirometer and the conventional spirometer. The order of the tests will be at random. They will also have their records reviewed and complete a validated symptom questionnaire. All study procedures will take place during their hospital stay. The results will be used to compare the devices to decide if we can accurately implement screening for COPD in patients with heart attack using the COPD-6 microspirometer, rather than having to undergo conventional spirometry.
REC name
West of Scotland REC 3
REC reference
25/WS/0043
Date of REC Opinion
13 Mar 2025
REC opinion
Favourable Opinion