SPICE III
Research type
Research Study
Full title
Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive Care
IRAS ID
164410
Contact name
Matt Wise
Contact email
Sponsor organisation
Australia and New Zealand Intensive Care (ANZIC)- Research Centre
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 1 months, 30 days
Research summary
Sedation Practices in Intensive Care Evaluation (SPICE).
The majority of critically ill patients admitted to intensive care require artificial ventilation and this requires the use of sedative drugs. Although the use of sedatives is ubiquitous throughout the world, the choice of which drugs or combination of drugs is optimal is unknown.
In recent years clinical practice has moved towards lighter levels of sedation when clinically safe, better management of pain and recognition of delirium (sometimes called 'acute confusional state'). Despite this during the early period of ventilation (within 48 hours) deep sedation is common and this correlates with a longer period of ventilation and increased death.
The current investigation is an international multi-centre study which aims to compare standard sedation protocols with a protocol of early goal directed sedation (titrating drugs to achieve light sedation).REC name
Wales REC 3
REC reference
14/WA/1205
Date of REC Opinion
20 Nov 2014
REC opinion
Further Information Favourable Opinion