SPECT-CT in Asymptomatic TKR

• Research type

  Research Study

• Full title

  A feasibility study to evaluate the natural history of periprosthetic radionuclide uptake observed during SPECT-CT* in each anatomical region of interest in participants with varying bone mineral densities who have a coincidental asymptomatic Total Knee Replacement who are undergoing nuclear medicine investigation for an alternative indication.

• IRAS ID

  295729

• Contact name

  Daniel Hill

• Contact email

  d.hill4@exeter.ac.uk

• Sponsor organisation

  University of Exeter

• Duration of Study in the UK

  1 years, 2 months, 30 days

• Research summary

  Most people are pleased with the outcome after their Total Knee Replacement. However some experience continued or new pain symptoms that we cannot explain. In some patients the cause is obvious, but for others it is very difficult for doctors to identify why a patient is not happy with their knee replacement.

  Sometimes surgeons use scans to try and identify the cause of pain. There are two types of scans we are interested in for this study. Because we never perform these scans on the knees of people who are happy with their knee replacement we do not know what a ‘normal’ scan looks like.
  
  1. SPECT-CT: this looks at the activity of the bone around a Total Knee Replacement. This is a scan performed in many hospitals to investigate patients who are not happy with their knee replacement.
  2. DEXA: this looks at how dense the bone is around a Total Knee Replacement. This is the type of scan normally used to diagnose osteoporosis. We would like to use it in this study to look at the bone around Total Knee Replacements.

  The purpose of this study is to collect information around what Total Knee Replacements look like on these scans in patients who are happy with their knee replacement. This will help us to evaluate scans in patients with pain in their knee replacement and indeed if an abnormal scan provides useful information.
  

• REC name

  London - Surrey Research Ethics Committee

• REC reference

  21/LO/0356

• Date of REC Opinion

  23 Jul 2021

• REC opinion

  Further Information Favourable Opinion