Specific electrophenotypes in atrial fibrillation

• Research type

  Research Study

• Full title

  IdeNtification of SPecific EleCTrophenotypes in Atrial Fibrillation – INSPECT-AF

• IRAS ID

  307933

• Contact name

  Fu Siong Ng

• Contact email

  f.ng@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Clinicaltrials.gov Identifier

  NCT05366530

• Clinicaltrials.gov Identifier

  21HH7349, Sponsor reference number

• Duration of Study in the UK

  4 years, 0 months, 1 days

• Research summary

  Summary of Research

  We will study a common heart rhythm disturbance (arrhythmia), atrial fibrillation (AF), to improve understanding of how best to treat it in different patients. Direct current cardioversion (DCCV) is a procedure that can revert the heart to a normal rhythm, however almost all patients will only have a transient benefit, and their heart will return to the abnormal rhythm, AF. Ablation is an invasive procedure that creates scar tissue within the heart to reduce the arrhythmias, with a longer lasting effect than DCCV. It has been used with success in AF that occurs occasionally (paroxysmal) but is not as effective in AF that is more long-lasting, also known as persistent AF. Persistent AF is major cause of symptoms of breathlessness and palpitations and significantly increases the risk of stroke. Doctors are unable to accurately predict which patients will benefit most from an ablation, this can lead to as many as 50% of patients not benefitting from the procedure. We aim to better predict which patients will benefit from an ablation. We will study patients undergoing AF ablation or DCCV and perform additional tests including blood tests a heart MRI scan, a special type of heart tracing with up to 252 points and a short period of extra recordings from within the heart during the ablation procedure. We will use several techniques to analyse this data, including machine learning, and develop a means predict which patients will benefit the most from the ablation procedure, without needing to use any recordings from within the heart.

  Summary of Results
  The study was stopped early due to new findings from other research that suggested this study was no longer had scientific value

• REC name

  London - Central Research Ethics Committee

• REC reference

  22/LO/0147

• Date of REC Opinion

  29 Mar 2022

• REC opinion

  Further Information Favourable Opinion