Spatial transcriptomics of lung tissue

  • Research type

    Research Study

  • Full title

    Spatially resolved host-pathogen interactions across the cystic fibrosis lung



  • Contact name

    Josephine M Bryant

  • Contact email

  • Sponsor organisation

    Genome Research Limited operating as The Wellcome Sanger Institute

  • Duration of Study in the UK

    3 years, 0 months, 0 days

  • Research summary

    People with cystic fibrosis are highly susceptible to bacterial infections, but many of these infections are extremely resistant to treatment and can persist for decades. We want to understand the host-pathogen interactions that allow the pathogens to survive in the lung and evade treatment. We will apply spatial transcriptomics to retrospectively collected lung tissue from transplant recipients to capture gene expression patterns of both human and pathogen origin.

    Samples will be selected from Duke University tissue bank and will be sent to the Wellcome Sanger Institute for DNA and RNA extraction and sequence analysis.

    There will be no patient interventions or identifiable information used in this study.

  • REC name

    South Central - Berkshire Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    8 Feb 2023

  • REC opinion

    Favourable Opinion