South Coast CLL and Lymphoproliferative Disorders (LPD)Tissue Bank
Research type
Research Tissue Bank
IRAS ID
92741
Contact name
David Oscier
Contact email
Research summary
South Coast CLL and Lymphoproliferative Disorders (LPD)Tissue Bank
REC name
South Central - Oxford C Research Ethics Committee
REC reference
14/SC/0162
Date of REC Opinion
2 Apr 2014
REC opinion
Favourable Opinion
Data collection arrangements
Patient recruitment, consent, sample collection and updating the clinical database will be undertaken by the clinical research team at each hospital site.
At the Royal Bournemouth Hospital NHS Foundation Trust, this includes consultant haematologists Professor David Oscier, Dr. Helen McCarthy, Dr. Renata Walewska, 3 dedicated haematology research nurses including one who works across the whole Dorset Cancer Network. Clinical and outcome data will also be collected by this team and entered onto a secure password protected NHS computer (to comply with data protection requirements) supported by the haematology research data and project managers at Bournemouth. Tissue will be stored at the Bournemouth site, batched and sent to the University Hospital Southampton NHS Foundation Trust for long-term storage.
The clinical research team at the University Hospital Southampton NHS Foundation Trust consists of Consultant haematologists Dr. Andrew Duncombe, Dr. Francesco Forconi and two haematology nurses. Clinical and outcome data will also be collected by this team and entered onto a secure password protected NHS computer (to comply with data protection requirements) supported by the haematology research data and project managers at Southampton.
Research programme
The use of stored tumour samples linked to biomarker and outcome data underpins research into the pathogenesis, natural history and treatment of leukaemia and other malignancies. Two established study specific tissue collections, situated in the Royal Bournemouth Hospital NHS Foundation Trust and University of Southampton, store samples from approximately 350 patients with CLL annually and have accrued presentation and sequential samples on over 2,200 patients with linked anonymised clinical and biomarker data and a median follow up over 7 years. This combined resource is used by both local and national research groups, the majority of which are LLR-funded. Data generated from these samples have been included in over 50 peer reviewed publications in the last 5 years. These activities will continue and be extended with the creation of the South Coast CLL and LPD Tissue Bank. This will provide a valuable resource to provide data to inform improved treatment of these diseases.
RTBTitle
South Coast CLL and Lymphoproliferative Disorders (LPD)Tissue Bank
Establishment organisation
University of Southampton
Establishment organisation address
Research governance office, Building 37, University of Southampton
Southampton
so17 1bj