Soul-Deep II:The South London Diabetes and Ethnicity Phenotyping study
Research type
Research Study
Full title
Soul-Deep II: the South London Diabetes and Ethnicity Phenotyping Study Phase II
IRAS ID
178092
Contact name
Louise Goff
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
3 years, 1 months, 26 days
Research summary
It is known that in the UK, people of Black West African (BWA) origin are at high risk of developing type 2 diabetes (T2D), leading to cardiovascular disease. The pre-diabetic state of ’insulin resistance’ has been recognised in this group; however distinct features are described. This research aims to provide a better understanding of the mechanisms by which T2D develops in BWA and White European (WE) people. Ultimately this will enable personalised treatment and prevention strategies to be developed, reducing the burden of T2D in this high risk ethnic group.
We will measure how well insulin is made in response to both a meal and to glucose (sugar) infusion and how sensitive people are to insulin’s action. We will measure how glucose and fat metabolism respond to insulin in both the liver and peripheral tissues (muscle and fat) using non-radioactive tracer technology and look at fat deposited around the waist, liver, pancreas and muscle with non-X-ray imaging in prediabetic and healthy people of BWA and WE ethnicity.
Males, 18-65 years old, of BWA and WE ethnicity, who are: [a] without a family history of diabetes and are normal glucose tolerant (NGT); [b] with a family history of diabetes and are prediabetic (impaired glucose tolerant, IGT), will be eligible to participate. A screening assessment, including family history, medical history and oral glucose tolerance test (OGTT: consumption of a sugar drink followed by test of blood sugar levels) will determine final eligibility. The research is conducted at King’s College and St Thomas’ Hospitals. Participants will attend four half-day assessments, spread out over 4-16wks, each after an overnight fast. Three visits will involve blood sampling, after the specific infusions or meal and one includes a visit to the scanning department for a MRI scan (shoulders to knees). The study is funded by Diabetes UK.REC name
London - London Bridge Research Ethics Committee
REC reference
15/LO/1121
Date of REC Opinion
14 Oct 2015
REC opinion
Further Information Favourable Opinion