S.O.S. V1.0

• Research type

  Research Study

• Full title

  A Measure for Sepsis Outcome in Scotland

• IRAS ID

  194863

• Contact name

  Meghan L Bateson

• Contact email

  meghan.bateson@uws.ac.uk

• Sponsor organisation

  University of the West of Scotland

• Duration of Study in the UK

  0 years, 8 months, 1 days

• Research summary

  Sepsis is often described as killing 44000 people in the UK per year (UK Sepsis Trust 2016). This estimate, however, is derived from a small selection of International Classification of Disease - 10th Revision (ICD-10) codes, of which there are known limitations.
  Accurately tracking the incidence and prevalence of the broader population of patients with sepsis would facilitate understanding of the epidemiology and enable evaluation of interventions to advance the recognition and management of sepsis. An ideal measure would be one which is “simple, objective, clinically meaningful, resistant to ascertainment bias and, ideally, suitable for automation using data routinely stored in electronic health records” (Rhee et al 2014). Currently, however, no such measure exists.
  This study will undertake a single centre case note review in a district general hospital to test and validate a measure which can reliably identify patients with sepsis from routine data. The use of routine data is important for detecting and tracking the outcomes of people with sepsis on a large scale. A validated measure would not only provide cost-effective epidemiological information but would allow impact evaluation of large scale changes in clinical practice. The results of this study will also inform ongoing debate and international work to optimise sepsis surveillance.

  This study is funded by the Fiona Elizabeth Agnew Trust.

  References
  - UK Sepsis Trust (2016) Our Statistics and Why it Matters. http://sepsistrust.org/our-statistics-and-why-it-matters-march-2016/
  - Rhee C, Gohil S, Klompas M. (2014) Regulatory Mandates for Sepsis Care – Reasons for Caution. N Engl J Med 370:1673-1676

• REC name

  West of Scotland REC 1

• REC reference

  17/WS/0044

• Date of REC Opinion

  15 Mar 2017

• REC opinion

  Favourable Opinion