SoDiUM Study
Research type
Research Study
Full title
The study of compartmental sodium distribution in patients with advanced kidney disease using a novel MR imaging technique
IRAS ID
166487
Contact name
Nicos Mitsides
Contact email
Sponsor organisation
Manchester University Foundation Trust
Duration of Study in the UK
1 years, 0 months, 2 days
Research summary
Salt causes high blood pressure and disease and death from heart and circulation health problems. Traditionally salt excess is linked with water excess and this is thought to be responsible for developing high blood pressure in prone individuals. As the kidneys are the main organs for balancing salt and water in the body, patients with chronic kidney disease are such a prone population. Current treatments for salt and water abnormalities are based around the close relationship of salt and water. However this relation does not entirely explain the effects seen in individuals on high salt diet. It has been proposed that salt can be stored independent of water. Although tests are available for measuring body water there are no tests available in clinical practice to measure salt. Salt stores were recently scanned using Magnetic Resonance Imaging (MRI) in healthy individuals and people with kidney disease on dialysis. The study of the body’s salt stores in haemodialysis patients showed that these can change quickly after dialysis treatment. These findings open a new avenue for investigating salt excess and tailoring treatment.
We aim to understand body salt distribution in dialysis patients that pass no urine, its interaction with fluid during haemodialysis and in-between dialysis treatments, and investigate factors that might influence salt stores using MRI. We would study associations between changes in body salt with hormone profiles and blood circulation measurements.
12 dialysis patients be studied using MRI with a specialised devised for picturing salt over 2 haemodialysis session. They will have a scan before dialysis, one immediately after dialysis and one just before their next treatment. Initial scans will be compared with scans from 10 healthy volunteers, 20 patients very close to starting dialysis (pre-dialysis) and 10 participants receiving extended haemodialysis (more than 12hr/week) as their routine treatment.REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
15/NW/0471
Date of REC Opinion
22 Jun 2015
REC opinion
Favourable Opinion