Sodium Fluoride PET CT in EVAR
Research type
Research Study
Full title
The PET-EVAR Study: Predicting endoleaks following Endovascular Aortic Aneurysm Repair using 18F-Sodium Fluoride
IRAS ID
254718
Contact name
David Newby
Contact email
Sponsor organisation
University of Edinburgh
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
The aorta is the main blood vessel which carries blood around the body. It can become diseased and increase in size (dilates), this is called an aneurysm. It can enlarge so much that it ultimately bursts. This is usually fatal and is the thirteenth leading cause of death in the United Kingdom. The dilatation is therefore usually repaired to prevent it from bursting. A modern approach to treatment uses a metal scaffolding to protect the diseased weak wall from the blood pressure, this is called a stent graft and is inserted from the groins. Whilst this is safe operation in the short term, in the longer term, blood can still leak behind the stent: either because the stent moves or because the aorta continues to dilate. Here we propose to test a new scanning technique to see if we can identify those patients who will or will not leak behind the stent. This means we could ultimately select the most appropriate treatment for patients.
We will perform two main studies - one will involve patients who have already had a stent put in and the other will involve patients who are going to have a stent put in. All participants will have an initial study scan and blood tests. In the second study participants will be followed up for two years after their stent is inserted with further imaging and blood tests at 12 months and a telephone consultation at 24 months. We have submitted a funding application to the British Heart Foundation for the project. Participants will be patients recruited from 4 vascular centres in Scotland.
REC name
South East Scotland REC 02
REC reference
20/SS/0119
Date of REC Opinion
23 Nov 2020
REC opinion
Favourable Opinion