Sodium balance in dialysis patients
Research type
Research Study
Full title
Pilot study to investigate sodium balance and the effect of sodium balance in dialysis patients
IRAS ID
288416
Contact name
andrew davenport
Contact email
Sponsor organisation
Joint Research Office (part of the Research Support Centre), UCL
Clinicaltrials.gov Identifier
Z6364106/2020/09/13, UCL Data Protection Registration; 136345, EDGE
Duration of Study in the UK
3 years, 9 months, 28 days
Research summary
The healthy kidney regulates sodium balance in the body. In patients with kidney failure, dialysis treatments are used to restore sodium balance. However, too much sodium can lead to retention of fluid and high blood pressure, resulting in heart failure, but on the other hand removing too much sodium with dialysis treatments can lead to low blood pressure and cramps. We wish to determine sodium balance in dialysis patients by estimating sodium intake by asking patients to complete our short questionnaire asking about eating foods which are high in salt used by our dietitians, measuring the amount of sodium removed in the waste dialysis water, and measuring blood pressure, and assessing their fluid balance when patients have their dialysis.
For the purposes of the PhD project in a small number of patients, we propose asking 10-20 patients who are found to be eating a high salt diet based on the questionnaires , we want to measure sodium in the skin and muscle in an arm or leg using a special scanner, called a magnetic resonance scan, and then determine whether this is associated with the amount of sodium removed in the waste dialysis water , blood pressure, fluid volume assessment.REC name
HSC REC A
REC reference
21/NI/0059
Date of REC Opinion
16 Mar 2021
REC opinion
Further Information Favourable Opinion