Social and cognitive predictors of treatment response in psychosis
Research type
Research Study
Full title
Mechanisms underlying treatment resistance in psychosis - Social and cognitive predictors of treatment response in psychosis (MUTRIPS-SoCoP)
IRAS ID
280715
Contact name
Reza Razavi
Contact email
Sponsor organisation
Institute of Psychiatry, King's College London
Duration of Study in the UK
3 years, 5 months, 1 days
Research summary
Around one third of people with a psychotic illness do not improve with our best available medical treatments. No improvement means that the psychotic symptoms remain, and continue to have an impact on the lives of patients, especially in the social domain, in relations and interactions with other people. This study aims to better understand the brain differences between participants with a psychotic illness who respond to treatment, those who don’t, and healthy participants. The main idea is that patients who don’t respond to treatment have a specific failure in the frontal parts of their brain, usually associated with more advanced control over other brain functions, such as learning. The study is in two parts, the first will use social and cognitive tasks during brain imaging to identify brain differences between participants with psychotic illness who respond to treatment, those who don’t respond, and healthy participants. We will only contact individuals who previously participated in the MUTRIPS study, and agreed to be contacted again. The second part of this study will test the association between these findings and the actual social life of the participant. We will investigate the social network they have, and participants will be monitored during a week, to record their activities and their experiences in social situations. If successful, identifying the brain regions related to treatment response could open the way for novel targeted therapy aimed at these brain areas, and social interventions aimed at increasing social involvement.
REC name
Wales REC 4
REC reference
20/WA/0192
Date of REC Opinion
21 Jul 2020
REC opinion
Further Information Favourable Opinion