Sleep-related respiratory dysfunction in atypical parkinsonism

• Research type

  Research Study

• Full title

  An exploratory study of sleep-related respiratory dysfunction in atypical parkinsonism

• IRAS ID

  157872

• Contact name

  Christopher Kobylecki

• Contact email

  christopher.kobylecki@manchester.ac.uk

• Sponsor organisation

  Salford Royal NHS Foundation Trust

• Duration of Study in the UK

  0 years, 11 months, 31 days

• Research summary

  Symptoms not relating to movement are becoming more recognised in Parkinson’s disease (PD) and related conditions (atypical parkinsonian syndromes). Breathing disorders in sleep are known to occur in atypical syndromes such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Sleep-disordered breathing can be fatal if it is not detected. Treatments such as breathing support (continuous positive airway pressure, CPAP) are available, but the best way to identify patients with these problems is not clear.
  This study will examine the occurrence of sleep-disordered breathing in patients who attend the Movement Disorder Clinic at Salford Royal NHS Foundation Trust(SRFT). This study aims to determine if we can reliably detect this problem using standard questionnaires. We plan to recruit 30 patients with MSA or PSP from our clinical service. They will undergo routine clinical assessment, including questionnaires addressing sleep problems, quality of life (QoL), memory and thinking, and other non-motor symptoms. Patients will then be referred for a sleep study. This will involve measurement overnight of breathing measures and oxygen levels in the blood using a probe attached to the finger. Patients who show sleep-disordered breathing will be offered CPAP and will attend sleep clinic to have this fitted, as would be standard clinical practice. All patients will be followed up as would be standard clinical practice, and the measures performed at baseline will be repeated over the follow-up period. This study will allow us to clarify the impact of these disorders on measures of QoL and aim to develop a multidisciplinary pathway for the best possible assessment and management.

• REC name

  East Midlands - Nottingham 1 Research Ethics Committee

• REC reference

  15/EM/0008

• Date of REC Opinion

  29 Dec 2014

• REC opinion

  Favourable Opinion