Sleep Disordered Breathing in Children with Primary Ciliary Dyskinesia
Research type
Research Study
Full title
Sleep Disordered breathing in Children with Primary Ciliary Dyskinesia
IRAS ID
130412
Contact name
Hui-leng Tan
Contact email
Sponsor organisation
Royal Brompton Hospital
Research summary
Primary ciliary dyskinesia (PCD) is an inherited condition that affects approximately 1 in 15 000 children in the UK. The cilia in the airways of patients with PCD do not beat effectively. The mucus in their airways is therefore not cleared well and they are prone to recurrent chest infections which can result in scarring of the lungs. Patients also often suffer from upper airway problems, such as sinusitis, blocked/ runny nose and build up of fluid behind the eardrums.
There is not much research on PCD, possibly because it is a relatively rare condition. The recent recommendations of the European Respiratory Society taskforce on PCD highlighted the urgent need for further research.
A recent paper has been published describing a very high incidence (52%) of obstructive sleep apnoea (OSA) in PCD patients. Obstructive sleep apnoea is when patients have episodes of obstruction of the upper airways during sleep, which can result in falls in oxygen levels, rises in waste gas (carbon dioxide) levels and disrupted sleep. This study was in a small number of Turkish patients (n=29) aged between 6months and 24 years.
We would like to see whether this problem is also seen in the PCD patients we look after. Therefore, we would like to study the sleep of children with PCD and determine whether they have disordered breathing (during sleep). We also hope to find out whether there is a relationship between upper airway inflammation, as measured in the fluid which lines the nose (described in greater detail in next section) and lower airway disease (lung function), markers of inflammation in blood and urine, Ear Nose and Throat symptoms, and severity and type of sleep disordered breathing.
REC name
London - Fulham Research Ethics Committee
REC reference
14/LO/1629
Date of REC Opinion
10 Dec 2014
REC opinion
Further Information Favourable Opinion