Sleep & Circadian Rhythms in People with Mild Cognitive Impairment V1
Research type
Research Study
Full title
Feasibility study to monitor sleep and circadian rhythms in people living with (mild) cognitive impairment or (mild) Alzheimer's disease and age-matched controls.
IRAS ID
311763
Contact name
Hana Hassanin
Contact email
Sponsor organisation
University of Surrey
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Sleep problems in dementia profoundly affect the wellbeing of those living with mild cognitive impairment or dementia and their caregivers. Disturbed sleep may be an indicator of disease progression or may in fact drive the development of the disease. As such, sleep is among the most promising targets for treatment in several different types of dementia. In order to effectively carry out long-term sleep monitoring at home, it requires technology that is acceptable, accurately measures sleep in those living with dementia, and is cost-effective.
In this study, we will evaluate the feasibility of assessing sleep in people living with mild cognitive impairment or mild Alzheimer's disease. In addition, we will assess these parameters in the study partners of the people living with dementia (PLWD) as there is limited data available on the impact of caring for PLWD on the sleep and circadian rhythms of the partner/family member/friend/support. We will also assess age-matched controls without dementia.
Roughly 50 participants will be recruited to the study in total. The research will last approximately 2 years, with individual participant involvement being around 15 days.
We will assess the acceptability and performance of a variety of sleep/circadian monitoring devices and the information obtained will also provide us with preliminary information about the relationship between disease status/ clinical symptoms and sleep/circadian rhythms. We will be collecting blood and urine samples for analysis of indicators of brain rhythms and function, including expression of genes known to vary with time of day and dementia risk.
This research may lead to the improvement of existing and the development of new technologies and approaches to monitor sleep and brain function. This involvement will help us gain initial data and a further understanding that will help guide future studies in dementia.
REC name
London - City & East Research Ethics Committee
REC reference
22/LO/0694
Date of REC Opinion
19 Oct 2022
REC opinion
Favourable Opinion