Sleep and physical activity in psoriatic arthritis
Research type
Research Study
Full title
A pilot study investigating mobile symptom collection, sleep quality and physical activity in psoriatic arthritis
IRAS ID
264240
Contact name
Laura Coates
Contact email
Sponsor organisation
University of Oxford, Clinical Trials and Research Governance
Duration of Study in the UK
0 years, 3 months, 31 days
Research summary
Research Summary
Psoriatic arthritis (PsA) is a chronic disease with a significant patient-perceived impact. Currently, the definitive goal of treatment is to prevent flares and induce remission.
Patient-reported outcome measures (PROs) have become a major tool in the assessment of PsA, with a number of domains most commonly cited as troublesome for patients including sleep disturbance, pain, reduced functioning. PROs, such as the Psoriatic Arthritis Impact of Disease (PsAID) and Health Assessment Questionnaire Disability Index (HAQ-DI) are validated questionnaires capture a wealth of subjective information on the impact of PsA.
To date, no study has employed the use of wearable accelerometers to objective measure physical activity and sleep quality in patients with PsA. This study will use a smartphone app to collect daily patient-reported information on symptoms and disease impact and correlate this with objective measures of functioning, collected through the accelerometers.
The aim of this study is to pilot the feasibility and tolerability of these novel digital health monitoring approach in patients with PsA, to get baseline physical activity measures with a view to employing these methods in interventional trials at a later date.
Summary of Results
This pilot study was set up to investigate the relationship between sleep impairment, physical activity and burden of psoriatic arthritis. We have conducted an initial analysis of baseline cross-sectional questionnaires which shows a moderately strong relationship between poorer sleep quality and disease activity, as measured using standardised questionnaires. In order to carry out this objective, we recruited 30 patients with a diagnosis of psoriatic arthritis from a single centre in the UK. At recruitment data, we collected a range of data on disease activity, baseline disease impact on the individual patient, functional impairment and sleep quality and impairment. We then gave participants a wrist worn accelerometer to wear for 28 days which measures sleep duration and interruption as well as activity levels across the period. Alongside this, we developed a smartphone application which gave participants the opportunity to answer daily questionnaires of symptom burden and sleep quality.
Initial results from the analysis of the baseline questionnaires have revealed that participants with increased disease impact have subjectively more impaired sleep. This correlation was also present for disease activity with those with more active psoriatic arthritis having subjectively worse self-reported sleep quality. Due to delays in data access, we have been unable to start analysis of the 28 day app and accelerometer data and this has just begun. We hope to share further results through dissemination in early 2023.
REC name
London - Central Research Ethics Committee
REC reference
19/LO/1193
Date of REC Opinion
9 Aug 2019
REC opinion
Further Information Favourable Opinion