SIS- Southend Imaging Study
Research type
Research Study
Full title
Southend Imaging Study
IRAS ID
187118
Contact name
Iris Grunwald
Contact email
Sponsor organisation
Southend University Hospital NHS Foundation Trust
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
At present, Magnetic Resonance Imaging (MRI) is widely used along with other tests to help diagnose dementia, however diagnosis still remains challenging. There is currently a focus on the usefulness of resting state functional MRI (RS fMRI) as a way of establishing differences in functional connectivity between healthy subjects and those with various neurodegenerative disorders. Although the potential for RS fMRI to be used as a biomarker for neurological diseases looks promising, further research is needed, especially regarding validation of normal values and seed-based functional connectivity. Further research into this area will help to improve the ability to appropriately classify new subjects and ultimately allow use of RS functional connectivity as a biomarker.
This is a non-treatment, prospective, natural history data collection that aims to analyse functional connectivity in a cohort of patients with suspected cognitive impairment. Correlation of global cognition and episodic memory performance-to-resting state fMRI functional connectivity will be evaluated.
Patient population will include patients over the age of 18 with cognitive impairment and age and gender matched controls. Eligible patients will have to complete neuropsychological and clinical assessments and complete an fMRI scan prior to enrolment.Study duration is estimated at 4 years.REC name
East of England - Essex Research Ethics Committee
REC reference
15/EE/0361
Date of REC Opinion
20 Nov 2015
REC opinion
Further Information Favourable Opinion