SIPUP
Research type
Research Study
Full title
A pilot study of the effect of prehabilitation on markers of sarcopenia in patients undergoing pancreatoduodenectomy for malignant disease.
IRAS ID
245689
Contact name
Saurabh Jamdar
Contact email
Sponsor organisation
Manchester University NHS Foundation Trust
Duration of Study in the UK
0 years, 5 months, 1 days
Research summary
This is a retrospective review of patient outcome who have already undergone pancreatic cancer surgery. The outcome of this study will have no impact on their current management. No patient recruitment is involved. The study wants to look at nutritional aspects on historical CT scans before and after a period of increased dietary input before surgical removal of cancer.
Cachexia (weakness and wasting of the body) is a hallmark feature of pancreatic cancer. Patients with features of cachexia have worse clinical outcomes. This includes a reduction in quality of life, reduced tolerance of therapy and a poorer prognosis. Sarcopenia, defined as a decreased muscle mass independent of fat mass, is a feature of the cachexia associated with pancreatic cancer. Patients with sarcopenia (loss of skeletal muscle mass, quality, and strength associated with aging) have progressive and generalised reduced muscle mass and function. In patients undergoing surgery for pancreatic cancer sarcopenia has been associated with increased rates of complication and worse survival. Treatment of sarcopenia is difficult but includes nutritional support and pancreatic enzyme replacement therapy (PERT) aimed at reducing malabsorption (inability to absorb certain nutrients and fluid.
Prehabilitation is a multimodal therapeutic regimen aimed at improving the overall physical condition of patients prior to surgery with the intention of reducing the incidence of perioperative complications. The impact of prehabilitation undertaken prior to pancreatic surgery on perioperative complication rates has not yet been investigated.
The aim of this study is to assess whether prehabilitation supervised by an appropriate multimodality team improves indices of sarcopenia in patients scheduled to undergo pancreatoduodenectomy.
REC name
London - Riverside Research Ethics Committee
REC reference
18/LO/1380
Date of REC Opinion
8 Aug 2018
REC opinion
Further Information Favourable Opinion