Siderophores for imaging infection using 68Ga-DFO v1.0
Research type
Research Study
Full title
Siderophores for Imaging Infection: A first-in-human pilot study using a tracer (68Ga-DFO) as proof of concept that siderophores can image bacterial infection in vascular grafts
IRAS ID
271229
Contact name
Sally Barrington
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
1 years, 8 months, 31 days
Research summary
This is a single center pilot study at Guy’s and St Thomas’ NHS Foundation trust involving a single study visit for participants, with remote follow up data collected at 24 hours, 3 months and 6 months later. There will be no changes to standard of care for participants. Participants will have an additional dynamic or static CT/PET scan
The purpose of this study is to find out if a new type of imaging tracer (68Ga-DFO) can be used to show infection in patients with vascular grafts using PET/CT scans. A PET-CT scan combines images from a CT (Computerised Tomography) scan and a PET (Positron Emission Tomography) scan. The CT scan takes a series of X-rays across the body and puts them together to create a 3-dimensional (3D) picture of tissues and organs inside the body. The PET scan uses a mildly radioactive tracer to show up areas of activity.
First a weakly radioactive tracer is injected then a PET/CT scan is done to see where the tracer has gone in the body. This tracer mimics particles that bacteria make to take up iron from the body to help them grow. We hope this new tracer will go to areas where bacteria are causing infection and so tell us if the graft is infected. We hope this type of tracer could be a better way to show infection than the tests currently used to diagnose infection.REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
20/EM/0092
Date of REC Opinion
9 Apr 2020
REC opinion
Favourable Opinion