Should all gas transfer measurements be corrected for baseline CO?
Research type
Research Study
Full title
A retrospective review to determine if all Gas transfer measurements should be corrected for a patient's baseline exhaled carbon monoxide concentrations.
IRAS ID
216364
Contact name
Martyn Bucknall
Contact email
Sponsor organisation
St Georges University of London
Clinicaltrials.gov Identifier
16.0223, Sponsor's reference number
Duration of Study in the UK
0 years, 6 months, 27 days
Research summary
Carbon monoxide is one of the gases that is used in gas transfer measurements. Both the ATS/ERS and ARTP guidelines consider baseline exhaled carbon monoxide levels as one of the factors that affects gas transfer results.
Thus, as my final year dissertation project, I will look at the significance of correcting gas transfer measurements (TLCO and KCO) for baseline carbon monoxide levels. Although my placement site measures exhaled CO in routine lab practice to identify smokers, they do not correct gas transfer results for this. As this information is recorded in routine clinical care at my placement site, I will be analyzing this data retrospectively.Although various research papers have looked at this area before, these papers are either dated and didn't really explore the effects of correcting baseline carbon monoxide levels on the classification of a patient's disease severity.
Data will be eligible if it includes individuals who are 18 or over who produced technically acceptable, reproducible results, smokers, non-smokers,ex- smokers, have a range of respiratory diseases and disease severity.Thus, this study will retrospectively consider on whether all gas transfer measurements should be corrected for exhaled baseline Carbon monoxide measurements. Furthermore, I aim to retrospectively find out the appropriate time a patient should stop smoking for prior to their gas transfer test by comparing each patient's exhaled baseline carbon monoxide levels with the time they last smoked. All the data available for this study is routinely collected as part of routine patient care.
The results of the gas transfer measurement that have been reported for clinical purposes will not be altered as part of this study.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
16/EE/0532
Date of REC Opinion
6 Dec 2016
REC opinion
Favourable Opinion