Severe Asthma & Cardiovascular Risk (SACVR) study
Research type
Research Study
Full title
Investigating the prevalence and correlates of Cardiovascular Risk in patients with Severe Asthma
IRAS ID
347691
Contact name
James Brown
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2024/11/16 medical research, UCL Data Protection Number
Duration of Study in the UK
1 years, 0 months, 7 days
Research summary
Asthma is a chronic lung condition affecting millions globally. Severe asthma, characterised by persistent symptoms despite high-intensity treatment, may increase the risk of cardiovascular disease (CVD), including heart attacks and strokes. This study aims to explore the potential link between severe asthma and cardiovascular risk and how biologic therapies might influence this risk.
Understanding this relationship is crucial for enhancing patient care. If a significant link is identified, it could lead to integrating cardiovascular risk assessments into asthma management plans, potentially reducing cardiovascular events and optimizing NHS resources.
This 3-month prospective observational study will recruit 50 participants from the Royal Free Hospital Severe Asthma Clinic. Baseline data will include demographics, medical history, and asthma severity. Cardiovascular risk factors such as hypertension, diabetes, and smoking will be assessed, alongside objective measures like lung function tests, arterial stiffness measurements, and retinal imaging.
Participants will undergo initial assessments and follow-up measurements to track changes over time, particularly those starting biologic therapy. Assessments will occur at baseline, at 3-months after initiating therapy.
Findings could improve clinical practices by emphasising cardiovascular risk assessment in severe asthma management, influencing NHS policies for routine cardiovascular evaluations, and personalised treatment plans. This research aims to enhance patient outcomes and reduce healthcare costs by preventing cardiovascular events in this high-risk group.
The study is funded by the Ministry of National Education Türkiye as part of the YLSY scholarship. Recruitment will occur at the Royal Free Hospital Severe Asthma Clinic.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
25/PR/0712
Date of REC Opinion
26 Aug 2025
REC opinion
Further Information Favourable Opinion