Service Evaluation of Lung SABR Planning comparing MCO & standard IMRT
Research type
Research Study
Full title
Does Multi-Criteria Optimisation (MCO) for Lung Stereotactic Ablative Radiotherapy (SABR) further reduce the dose received to the Chest Wall whilst maintaining adequate PTV coverage, in comparison to current practice?
IRAS ID
250239
Contact name
Laura Ferguson
Contact email
Sponsor organisation
University of Dundee
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
This project is a service evaluation, comparing the current method of optimising Lung Stereotactic-Ablative Radiotherapy (SABR) cancer planning, against an advanced optimisation method, Multi-Criteria Optimisation (MCO). Lung SABR treatment is a high dose, low fractionation Radiotherapy regime offered to eligible patients that meet a strict criteria, who may otherwise be unsuitable for surgery.
An aim of this project is to investigate if the plans produced by traditional optimisation methods can be further improved, specifically, with regards to reducing the radiation dose to the Chest Wall, by using MCO. This is to ensure that patients are receiving the best quality plans possible. The potential foreseen benefits of using MCO SABR Planning include, the patient receiving less radiation dose to the Chest Wall, which may reduce the risk of possible side effects including Chest Wall pain, rib fractures and skin reactions.
This project will specifically assess the Radiotherapy Planning CT Data of historical Lung Cancer patients, who have already consented to their originally planned Radiotherapy treatment and will not be receiving a new or different treatment from what was originally approved of by the Clinician.
Each historical case would be re-planned, using MCO and evaluated with the Departmental Protocol, assessing tumour coverage and Chest Wall dose. Applicable statistical testing applied. The original and MCO plans compared and evaluated.
All patient data will be anonymised and duplicated within a separate training area of the Treatment Planning Software (TPS). Collection and access to data will be undertaken with the Radiotherapy (RT) Department, Ninewells Hospital, NHS Tayside, using the Investigators Hospital account (password protected, NHS Tayside server). The TPS is only accessible to those competent in its use and is login and password protected. All planning data is backed up nightly and over the weekend to ensure no loss of data.
This service evaluation is part of a Dissertation Masters (Msc) Module in Radiotherapy Planning and will take one year to complete.REC name
East of Scotland Research Ethics Service REC 1
REC reference
18/ES/0137
Date of REC Opinion
27 Nov 2018
REC opinion
Favourable Opinion