SELFIE

• Research type

  Research Study

• Full title

  OPTIMISING MOLECULAR RADIONUCLIDE THERAPY: The Role of Quantitative SPECT/CT, PET/CT and Radiation Dosimetry (SELFIE)

• IRAS ID

  288352

• Contact name

  V Lewington

• Contact email

  valerie.lewington@kcl.ac.uk

• Sponsor organisation

  King’s College London

• Duration of Study in the UK

  1 years, 0 months, 0 days

• Research summary

  Molecular radiotherapy (MRT) uses licensed radioactive medicines to treat benign and malignant disease. The amount of radioactive medicine administered to a patient is determined clinically within an agreed reference range. Although outcomes depend on the radiation dose delivered to the target tissue and normal organs, this is very difficult to measure accurately. As a result, routine practice internationally assumes that ‘one size fits all’ and does not allow the amount of MRT prescribed to be adjusted on an individual patient basis.
  Patients routinely undergo pre and post-treatment scans to confirm their eligibility for treatment and assess response. After treatment, patients are radioactive and need to limit their contact with other people for up to 3 weeks. The duration of restrictions is not personalised, so maybe longer than necessary and burdensome for patients to adhere to.

  Part 1 A nuclear medicine quantitative method will be applied to analyse the scans of MRT patients undergoing treatment for benign thyroid disease, thyroid cancer and neuroendocrine tumours. These data will be used to estimate the radiation dose delivered to target and normal tissues and then to correlate dose received with clinical outcomes. If successful, this approach would support individualised MRT prescription i.e.: personalised treatment.
  Part 2 Patients will be taught how to record their own radiation levels at home after treatment using handheld dose measurement devices. When integrated with the results of scan analysis, these data will increase the precision of radiation dose measurements. These data might also allow post-radiation protection restrictions to be personalised, potentially improving patient experience.
  The radiation exposure of patients recruited to the study will be solely received as part of their routine clinical care.

• REC name

  South Central - Hampshire B Research Ethics Committee

• REC reference

  21/SC/0262

• Date of REC Opinion

  18 Oct 2021

• REC opinion

  Further Information Favourable Opinion