Selective Coronary vein sampling in LBBB and CRT
Research type
Research Study
Full title
The effects of pacing on cardiac work on patients in Left bundle branch block and following cardiac resynchronisation therapy
IRAS ID
159013
Contact name
Christopher Aldo Rinaldi
Contact email
Sponsor organisation
Guy's & St Thomas' Foundation NHS Trust
Research summary
Cardiac resynchronisation therapy (CRT) prolongs the life and improves the symptoms in patients with heart failure and electrical dyssynchrony. 30-50% of patients do not improve with the treatment which is both expensive and not without complication. Despite much research, we cannot accurately predict who will not respond. Furthermore, most heart failure patients gets symptoms on exercise and most studies have examined patients at rest. We propose to investigate the effect of exercise on different parts of the left ventricle by sampling various biomarkers of metabolism, myocardial injury and gene expression. We will then repeat the protocol following device insertion to look for changes. We will assess cardiac work to ensure any biochemical changes relate to these. This novel work will require a small cohort of patients with heart failure and no electrical dyssynchrony and normal patients to act as controls. We will also measure novel biomarkers at different venous sites relating to different parts of the myocardium to determine whether they can be used to prognosticate or even predict responsr to CRT.
REC name
London - Westminster Research Ethics Committee
REC reference
14/LO/1725
Date of REC Opinion
24 Oct 2014
REC opinion
Further Information Favourable Opinion