SELECT: Salt sEnsitivity bLood prEssure CoarctaTion
Research type
Research Study
Full title
Salt Sensitivity of Blood Pressure in Coarctation of the Aorta
IRAS ID
336411
Contact name
Michael Quail
Contact email
Sponsor organisation
University College London
Clinicaltrials.gov Identifier
Z6364106/2024/08/48, UCL data protection registration number; N/A, UCLH BRC
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Hypertension is common in adult patients following repaired coarctation of the aorta and the reason for this, in the absence of arch obstruction, remains unclear. Salt sensitivity of blood pressure (SSBP) is a risk factor for hypertension and we propose this to play a vital role in development of hypertension in this cohort. Elevated blood pressure (BP) leads to early cardiovascular complication; such as heart attack and stroke and so understanding the underlying mechanism and targets for treatment are imperative.
The main purpose of this study is to look at the relationship between salt sensitivity and BP; assessing the impact of low and high salt diet. The relationship between dietary sodium and BP has not been studied in repaired Coarctation patients, however several physiological abnormalities (renal and autonomic) may specifically increase the risk of abnormal BP response in this group. We will look at the impact on the haemodynamics and autonomic function in repaired coarctation patients and healthy controls, including imaging with cardiac MRI and Sodium MRI to quantify central haemodynamics, aortic stiffness and skin sodium concentrations.
The project being conducted will form part of a PhD thesis.
REC name
London - Westminster Research Ethics Committee
REC reference
24/LO/0816
Date of REC Opinion
24 Dec 2024
REC opinion
Further Information Favourable Opinion