SEDIVOC-B
Research type
Research Study
Full title
Swab based Early Detection of Infection by Volatile Compounds in Burns
IRAS ID
337241
Contact name
Christopher Wearn
Contact email
Sponsor organisation
University Hospitals Bristol and Weston NHS Trust
Clinicaltrials.gov Identifier
CH/2024/7791 , Sponsors Reference Number
Duration of Study in the UK
0 years, 9 months, 30 days
Research summary
This study will look at the gases released from wound swabs taken from adults and children with burn injuries as a method of detecting wound infection. For this study we will be asking patients and parents of children with burns if we can take an extra wound swab during their dressing change and send it to a university laboratory. The swabs will be analysed at the university using laboratory instrumentation this is capable of differentiating smells (volatile compounds) which indicate the presence of bacteria.
Basic demographic data will be collected including, but not limited to: age, gender, date of injury, cause of injury, type of burn (scald, flame, contact), depth of burn, location of the burn on the body, and clinical signs of infection including local swab results. This data will only be able to be linked back to the patient with a unique study identification number. This will be securely stored in the site file at the clinical study sites. If as a part of the patient's routine treatment there is a requirement for blood tests these tests will be linked back anonymously to the study findings.
The knowledge gained within this study will inform a future study to develop a point of care bedside device for burn wound infection detection based on gas sensors that could either be used at the bedside or integrated into dressing technology.
REC name
West of Scotland REC 4
REC reference
25/WS/0050
Date of REC Opinion
24 Apr 2025
REC opinion
Further Information Favourable Opinion