SECRETO version 3.0
Research type
Research Study
Full title
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome
IRAS ID
249458
Contact name
Anu Eräkanto
Contact email
Sponsor organisation
Helsinki University Hospital, Neurocenter, Dept. of Neurology
Clinicaltrials.gov Identifier
Duration of Study in the UK
11 years, 2 months, 31 days
Research summary
Annually, approx. 1.3 million ischemic strokes occur worldwide prematurely in adults aged 18 to 49 years. In at least 1/3 of the patients, the underlying cause of the stroke remains unclear despite extensive investigations (cryptogenic stroke). The aim of this study is to decipher transient triggers, chronic subclinical and clinical risk factors, and genetic factors underlying early-onset cryptogenic ischemic stroke after comprehensive diagnostic work-up as well as to study long-term prognosis after such events. No new drugs or devices are being studied.
Our global aim to enroll 600 patients aged 18-49 years with first-ever imaging-positive cryptogenic ischemic stroke after comprehensive standardized diagnostic workup and 600 stroke-free control subjects matched to patients’ gender, ethnicity and age. The study will be conducted in university hospitals, central hospitals and neurocenters mostly in Europe but also in Australia and in North- and South-America.REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
18/NW/0756
Date of REC Opinion
14 Feb 2019
REC opinion
Further Information Favourable Opinion