SCOT-HEART KIDNEY 2
Research type
Research Study
Full title
Computed Tomography Coronary Angiography to Predict Chronic Kidney Disease (SCOT-HEART KIDNEY 2)
IRAS ID
354597
Contact name
Neeraj Dhaun
Contact email
Sponsor organisation
University of Edinburgh
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Kidney disease and heart disease are closely linked, with heart disease the main cause of death in patients with kidney disease. Kidney disease is a progressive condition that can result in kidney failure. The earlier you detect kidney disease, the sooner treatments can be started to slow down the progression of the disease and improve outcomes. There are two ways to detect kidney disease: either through a blood test or by a urine sample. In the earliest stages of kidney disease (i.e., when it is most mild) it is usually only detectable on a urine sample.
We have previously found that patients with chest pain who have evidence of heart disease on a scan of their heart (called a CTCA scan) are at higher risk of developing kidney disease over the next 5-10 years. However, our findings were limited as we did not have urine samples available and the same may not be true in individuals without chest pain.
The SCOT-HEART 2 study is a randomised trial that is recruiting at least 6,000 middle-aged people in Scotland who are at risk of heart disease and will compare two ways of deciding which treatment to give them: 1) Working out a risk score based on clinical characteristics; or 2) Giving them a CTCA scan. We would like to collect urine samples in all people taking part in this study to see 1) if a heart scan can predict future kidney disease in the general population and 2) to see if having treatment guided by a heart scan can reduce your risk of future kidney disease. Urine samples are essential to ensure participants don't have kidney disease at baseline.
REC name
West Midlands - Black Country Research Ethics Committee
REC reference
25/WM/0041
Date of REC Opinion
26 Feb 2025
REC opinion
Favourable Opinion