SCOPE-COPD
Research type
Research Study
Full title
Systematic characterisation of pre-chronic obstructive pulmonary disease (COPD) & COPD Observational Cohort Study (SCOPE-COPD)
IRAS ID
350471
Contact name
Marie Fisk
Contact email
Sponsor organisation
Cambridge University Hospitals NHS Foundation Trust
Duration of Study in the UK
10 years, 0 months, 0 days
Research summary
Background:
Chronic obstructive pulmonary disease (COPD) is a common condition that affects millions of people in the UK. A diagnosis of COPD means that long-term airflow obstruction is established, and irreversible lung or airway changes have already occurred. There are many different pathological processes that occur in COPD.
The aim of this study is to understand the pathology of the development of COPD (pre-COPD) and COPD. So, in the future, we may be able to prevent disease progression and change outcomes for patients.
What is involved:
This is an observational study of 150 people with COPD and 50 people with pre-COPD (at risk of COPD), compared to 80 people without COPD (controls). Participants will have detailed baseline assessments. This involves questionnaires, lung function tests, bloods, phlegm, nasal fluid and stool samples if possible. It also involves CT scans of the lungs at baseline. If a participant consents to it, and based on these baseline assessments, some participants may also have a bronchoscopy. This is a camera test of the lungs, where samples are also taken. This helps get direct samples of the lungs which is really important to improve disease understanding.
Participants in the study will be followed up with yearly for up to 3 years, with repeat lung function, bloods and phlegm sampling for example and further repeat CT scans of their lungs at about 2-3 years from entering the study.
After this, there is an annual follow up questionnaire for up to 10 years in total.
Any clinical diagnoses detected during the study will be managed by the clinical research team to ensure all clinical care follow up is made.
It is hoped this study will further understanding about COPD and the development of COPD; to help future patients and prevent irreversible lung damage from occurring.REC name
Wales REC 5
REC reference
25/WA/0365
Date of REC Opinion
14 Jan 2026
REC opinion
Further Information Favourable Opinion