SCD-Well Blood Storage
Research type
Research Study
Full title
Blood storage for: A multicentre randomised superiority study to compare the effects of an 8-week mindfulness-based intervention versus health education programme on mental health and wellbeing in individuals with Subjective Cognitive Decline.
IRAS ID
273157
Contact name
Natalie Marchant
Contact email
Sponsor organisation
Institut National de la Sante et de la Recherch Medicale (INSERM) PRC
Duration of Study in the UK
15 years, 0 months, 0 days
Research summary
This study relates to the European Commission funded, ethically approved and completed SCD-Well trial.
Briefly, the SCD-Well trial investigated the effects of two behavioural interventions (mindfulness versus health education) on anxiety levels and a broad range of other outcomes (including blood-based biological markers) in individuals with Subjective Cognitive Decline (SCD). Individuals with SCD believe that their thinking and/or memory have declined but still score within the normal range on tests for dementia. People with SCD are at an increased risk of developing dementia.
During the SCD-Well trial behavioural assessments and blood draws were taken from participants at baseline, after an 8-week behavioural intervention and at follow-up (16 weeks after the intervention). Recent evidence suggests that behavioural interventions (such as 8-week mindfulness interventions) have the potential to increase blood-based biological markers that appear to protect against both stress and dementia in at risk older adults.
Ethical approval has already been granted to analyse the potential affects the behavioural interventions may have upon blood-based biological markers that appear to protect against both stress and dementia. However, until the planned analyses are conducted the integrity of the blood samples needs to be maintained. Storing blood in a very cold temperatures (i.e. in a -80 degree freezer) helps to maintain the integrity of the blood samples.
REC name
London - Camden & Kings Cross Research Ethics Committee
REC reference
20/LO/0292
Date of REC Opinion
25 Mar 2020
REC opinion
Further Information Favourable Opinion