SARAH pilot study

• Research type

  Research Study

• Full title

  A pilot study into health pre and post treatment with intravenous Aminophylline and Hydrocortisone in severe asthmatics

• IRAS ID

  147348

• Contact name

  Andrew Menzies-Gow

• Contact email

  a.menzies-gow@rbht.nhs.uk

• Sponsor organisation

  The Royal Brompton and Harefield NHS Trust

• Eudract number

  2014-000182-45

• ISRCTN Number

  xx

• Clinicaltrials.gov Identifier

  xx

• Research summary

  Despite evolving treatments, a significant number of asthmatic patients have difficult to control asthma. This severe asthma is problematic for the patient and new treatments are needed. The Royal Brompton treat severe asthmatics with a 7-10day
  regimen of intravenous aminophylline and hydrocortisone and anecdotal evidence suggests this reduces symptoms and increases control of exacerbations. Research is needed to understand why it is beneficial to this group of patients, attempt to improve the quality of life of severe asthmatics, with the intention of incorporating this treatment into guidelines in the future. This is a pilot study, examining symptoms,lung function, quality of life, exercise tolerance, cardiovascular function and presumed change in inflammatory profile in
  severe asthmatics, pre and post treatment.

• REC name

  London - Brent Research Ethics Committee

• REC reference

  14/LO/0274

• Date of REC Opinion

  2 Apr 2014

• REC opinion

  Further Information Favourable Opinion