Salt and PD
Research type
Research Study
Full title
Relationship between sodium output, hydration and peritoneal dialysis technique survival.
IRAS ID
258934
Contact name
Stanley Fan
Contact email
Sponsor organisation
Queen Mary college, University of London
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Peritoneal dialysis (PD) is one form of dialysis that patients with kidney failure can do every day in their own home to manage the work of the kidneys. The kidneys normally remove toxins and excess fluid. During PD, toxins and excess fluid pass through a natural membrane within the abdomen into the dialysis fluid, which is then drained out and discarded. The inability for excess fluid to pass through the membrane leading to fluid overload is one of the reasons for PD technique failure.
As a part of water regulation in the body, water follows electrolytes such as sodium. The aim of the study is to explore whether sodium removal (through PD and urine) would significantly impact on PD technique. Thereby establish the relationship between sodium removal, PD adequacy, hydration status and PD technique survival.
By understanding the role of sodium removal in PD, we wish to determine the relationship between traditional parameters creatinine clearance and kt/v (clearance of urea in time over the volume of distribution) to quantify PD treatment adequacy.
REC name
North East - Newcastle & North Tyneside 2 Research Ethics Committee
REC reference
19/NE/0059
Date of REC Opinion
6 Feb 2019
REC opinion
Favourable Opinion