Salivary Cortisol MSc Project

• Research type

  Research Study

• Full title

  Verification of salivary cortisol and cortisone ELISA assays, and investigation into their utility in monitoring paediatric congenital adrenal hyperplasia (CAH) and hypopituitarism patients on hydrocortisone replacement.

• IRAS ID

  267037

• Contact name

  Katherine Wright

• Contact email

  katherine.wright2@nhs.net

• Sponsor organisation

  Doncaster & Bassetlaw Teaching Hospitals NHS Foundation Trust

• Clinicaltrials.gov Identifier

  N/A, N/A

• Duration of Study in the UK

  0 years, 11 months, 30 days

• Research summary

  There is evidence in the literature that salivary cortisol/cortisone day curves may be of use in monitoring and optimising hydrocortisone therapy. This study aims to contribute to the evidence in a paediatric population through the following objectives:
  1. Verification of commercial salivary cortisol and cortisone ELISA assays.
  2. Contribute to data to establish the ‘normal’ ranges for salivary cortisol
  and cortisone throughout the day in a paediatric population.
  3. Investigate the utility of salivary cortisol and cortisone day curves in monitoring paediatric CAH/hypopituitarism patients on hydrocortisone replacement. (Investigated by comparing day curves in these patients to those of an age-matched normal population, and considering this in the context of other clinical and hormonal parameters currently used).

• REC name

  London - Harrow Research Ethics Committee

• REC reference

  19/LO/1562

• Date of REC Opinion

  16 Sep 2019

• REC opinion

  Favourable Opinion