Salivary cortisol and salivary cortisone in children on hydrocortisone
Research type
Research Study
Full title
A study of salivary cortisol measurement in children treated with hydrocortisone
IRAS ID
209817
Contact name
Joanne Blair
Contact email
Sponsor organisation
Alder Hey Children's NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
We aim to measure the difference in salivary biomarkers in children aged between 3 and 18 years, with adrenal insufficiency (AI) condition (e.g. congenital adrenal hyperplasia (CAH), administered with 2.5 mg or 7.5mg oral hydrocortisone derived from 10mg tablets, to determine whether adequate doses are received when administered in this way.
This is important as inadequate treatment puts the patient at risk of adrenal crisis and their quality of life is also likely to be affected adversely by the chronic symptoms of adrenal insufficiency. In addition, failure to suppress adrenocorticotropic hormone (ACTH) in patients with CAH results in increased adrenal androgen secretion, virilisation, accelerated growth and skeletal maturation.REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
16/EM/0294
Date of REC Opinion
2 Aug 2016
REC opinion
Further Information Favourable Opinion