Salivary Antimicrobial Molecule in Tooth Decay (Caries) in Children.
Research type
Research Study
Full title
Dental Treatment and the Antimicrobial Peptide LL-37 in Children with Caries.
IRAS ID
255435
Contact name
Fatemah Almusaileekh
Contact email
Sponsor organisation
University of Leeds
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 3 months, 1 days
Research summary
Dental caries is the most widespread non-communicable disease that has a negative impact on children. It is significantly affects the oral health of children and has significant systemic, psychological and social consequences. Multiple approaches are available to manage and treat dental decay, but few tools are available to predict and prevent its occurrence. The aim of this research is to study the association between the naturally occurring antimicrobial molecule in saliva (LL-37) and dental caries in children. We aim ultimately to determine the value of LL-37 as a prediction tool for caries risk in children. Children who are scheduled to receive dental treatment under a general anaesthetic will be invited to participate. Saliva will be collected from the participants on the day of the appointment prior to their treatment. A second saliva sample will be collected from the same participants one month after their dental treatment during their routine review appointment. The research will also involve data collection from dental records. Data collected will include demographic data, examination records, and treatment records. \nAll saliva samples will be processed and analysed in laboratory in the Wellcome Trust Brenner Building (WTBB), St James’s University Hospital.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
19/YH/0119
Date of REC Opinion
23 Apr 2019
REC opinion
Favourable Opinion